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TMC435-<sup>13</sup>C,d<sub>3</sub>

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Cat. No. Product Name Target Research Areas Chemical Structure
  • HY-10241S
    Simeprevir-13C,d3

    TMC435-<sup>13sup>C,d<sub>3sub>; TMC435350-<sup>13sup>C,d<sub>3sub>

    		 Isotope-Labeled Compounds HCV HCV Protease SARS-CoV DNA/RNA Synthesis Infection
    Simeprevir- 13C,d3 is the 13C- and deuterium labeled Simeprevir. Simeprevir is an oral, potent and highly specific hepatitis C virus (HCV) NS3/4A protease inhibitor with a Ki of 0.36 nM. Simeprevir inhibits HCV replication with an EC50 of 7.8 nM. Simeprevir also potently suppresses SARS-CoV-2 replication and synergizes with Remdesivir. Simeprevir inhibits the main protease (Mpro) and the RNA-dependent RNA polymerase (RdRp) of SARS-CoV-2, and also modulates host immune responses[1][2][5].
    Simeprevir-13C,d3

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